- Original Article
- Infection
- Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
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Eunjin Choi, Kee-Soo Ha, Dae Jin Song, Jung Hwa Lee, Kwang Chul Lee
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Clin Exp Pediatr. 2018;61(6):180-186. Published online June 25, 2018
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Purpose Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. MethodsMultiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013... |
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- Case Report
- Immunology
- Familial Mediterranean fever presenting as fever of unknown origin in Korea
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Jun Hee Lee, Jong Hyun Kim, Jung Ok Shim, Kwang Chul Lee, Joo Won Lee, Jung Hwa Lee, Jae Jin Chae
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Clin Exp Pediatr. 2016;59(Suppl 1):S53-S56. Published online November 30, 2016
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Familial Mediterranean fever (FMF) is the most common Mendelian autoinflammatory disease, characterized by uncontrolled activation of the innate immune system that manifests as recurrent brief fever and polyserositis (e.g., peritonitis, pleuritic, and arthritis). FMF is caused by autosomal recessive mutations of the Mediterranean fever gene, MEFV which encodes the pyrin protein. Although FMF predominantly affects people from Mediterranean and Middle... |
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- Original Article
- Alteration of CD4+CD25+Foxp3+ T cell level in Kawasaki disease
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Su Ye Sohn, Young Wooh Song, Yun Ku Yeo, Yun Kyung Kim, Gi Young Jang, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee
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Clin Exp Pediatr. 2011;54(4):157-162. Published online April 30, 2011
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Purpose Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD. MethodsPeripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25,... |
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- Case Report
- A childhood case of spinal tuberculosis misdiagnosed as muscular dystrophy
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Doo Il Song, Su Ye Sohn, Yun Kyung Kim, So Hee Eun, Young Jun Rhie, Gi Young Jang, Chan Wook Woo, Byung Min Choi, Jung Hwa Lee, Bo Kyung Je
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Clin Exp Pediatr. 2010;53(5):657-660. Published online May 31, 2010
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Tuberculosis is primarily a pulmonary disease, but extra-pulmonary manifestations are not uncommon, especially in children and adolescents. Ten percent of extra pulmonary tuberculosis localizes to the bones and joints, and 56% of such cases affect the spine. We treated a childhood case of spinal tuberculosis misdiagnosed as muscular dystrophy in a patient without specific constitutional symptoms. We report this case... |
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- Original Article
- Relationship between the depth of cingulate sulcus on neonatal high
resolution cranial ultrasound and gestational age
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Young Chil Choi, Jin Yong Choi, Jung Hwa Lee
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Clin Exp Pediatr. 2009;52(10):1136-1139. Published online October 15, 2009
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Purpose : It is critical that the exact gestational age of a newborn baby, especially premature baby, be determined to evaluate the status of a disease and its management and to estimate the prognosis of a patient. This study aimed to investigate an easy and accurate method to estimate gestational age on cranial ultrasound, requiring minimal additional time and equipment.
Methods... |
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- Case Report
- Cerebro-oculo-facio-skeletal syndrome : A case report
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So Hee Lee, Seong Jin Hong, Jung Hwa Lee, Soo Yun Oh, Sun Heum Kim, Duk Hwan Kho, Kyo Sun Kim
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Clin Exp Pediatr. 2008;51(4):435-438. Published online April 15, 2008
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The Cerebro-oculo-facio-skeletal (COFS) syndrome is a rare autosomal recessive disorder characterized by multiple abnormalities that involve the brain, face, eyes, and extremities. COFS syndrome is regarded as a degenerative disorder of the brain and spinal cord caused by a mutation of the DNA repair genes. We report on an 8-month-old girl with COFS syndrome who exhibited growth and developmental delay,... |
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- Original Article
- Alteration of insulin resistance and serum adiponectin levels after one year follow-up of obese children and adolescents
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Min Jee Jeoung, Jung Yeon Shin, Soo Young Kim, Jung Hwa Lee, Kee-Hyoung Lee, Joo Won Lee
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Clin Exp Pediatr. 2007;50(8):767-773. Published online August 15, 2007
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Purpose : Obesity has become a pandemic and especially the prevalence of childhood obesity has increased remarkably over the past years. Childhood obesity is often accompanied by the expected morbidities such as hyperlipidemia, fatty liver and glucose intolerance. We evaluated the pattern of alteration in the body mass index (BMI), serum adiponectin concentration, insulin resistance (HOMA-IR), and complication rates after... |
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- Case Report
- A case of lung abscess caused by Burkholderia cepacia in healthy child
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Jung Hwa Lee, So Hee Lee, Seong Jin Hong, Young Chil Choi, Eun Gu Hwang
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Clin Exp Pediatr. 2007;50(1):89-94. Published online January 15, 2007
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Burkholderia cepacia is a Gram-negative aerobic bacillus known to cause opportunistic infections in the immune-compromised hosts. This microorganism is strongly virulent and causes a necrotising invasive infection that may lead to death. As B. cepacia is highly resistant to various antimicrobials, combination antimicrobial therapy must be used instead of monotherapy. We report a successful treatment of lung abscess that was... |
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- Original Article
- Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
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Jung Hwa Lee, So Hee Lee, Sang Taek Lee, Yong Hyun Park, Seong Jin Hong
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Clin Exp Pediatr. 2006;49(7):790-795. Published online July 15, 2006
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Purpose : This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD).
Methods : Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to... |
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- Case Report
- A Case of Chylous Mesenteric Cyst in a Neonate
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Hyun Taek Lim, Jung Hwa Lee, So Hee Lee, Jeong Eun Kim, Seong Jin Hong, Young Chil Choi, Sang Yun Kim
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Clin Exp Pediatr. 2005;48(5):569-571. Published online May 15, 2005
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Mesenteric cysts are one of the least common intraabdominal lesions, which are very rare in neonates. Among mesenteric cysts, a chylous cyst is the rarest one of all. This entity can be found anywhere in the gastrointestinal tract from the duodenum to the rectum. Mesenteric cysts may be asymptomatic and found on routine examinations, or can present with symptoms such... |
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- Original Article
- A Domestic Outbreak of Bacterial Dysentery Caused by Extended-Spectrum β-Lactamase(ESBL)-producing Shigella sonnei
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Hyun Taek Lim, So Hee Lee, Jung Hwa Lee, Jeong Eun Kim, Kyo Sun Kim, Eun Ju Jeong, Seung Hyun Lee, Chang Gyu Kang, Seong Jin Hong
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Clin Exp Pediatr. 2005;48(10):1107-1115. Published online October 15, 2005
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Purpose : An outbreak of ESBL-producing Shigella sonnei enteritis was unprecedented not only in Korea but throughout the world in the past. We intended to devise a management guideline for ESBL-producing shigellosis based on analysis of clinical manifestations and response to therapy.
Methods : We analyzed 103 patients who were admitted to the hospital with acute GI symptoms and were... |
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- Case Report
- A Case of Measles Encephalopathy with Thalamic Lesion on
Magnetic Resonance Imaging
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Dae Hun Pee, Dae Jin Song, Young Kyoo Shin, Jung Hwa Lee, Kee Hyoung Lee, Baik Lin Eun, Sang Hoon Cha
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Clin Exp Pediatr. 2001;44(8):936-941. Published online August 15, 2001
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We experienced a case of measles encephalopathy with thalamic lesion on magnetic resonance imaging(MRI) in a 12 year old boy. Measles symptoms such as fever, erythematous maculopapular rashes on whole body and cough with sputum appeared 4 days before neurologic signs such as agitation and drowsy-to-confused mentality. He showed remarkable motor dysfunction without evidence of sensory loss. MRI showed bilateral... |
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- Original Article
- Postnatal Changes in Left Ventricular Performance in Early Neonatal Life
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Sung Wook Yang, Chan Wook Woo, Jee Youn Lim, Jung Hwa Lee, Joo Won Lee, Chang Sung Son, Young Chang Tockgo, Young Yoo
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Clin Exp Pediatr. 2000;43(9):1168-1173. Published online September 15, 2000
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Purpose : This study was undertaken to investigate changes in cardiac performance in early neonatal life by observing the changes of left ventricular(LV) function and volume according to the size of ductus arteriosus.
Methods : The study group consisted of 21 full-term Cesarean section neonates who were admitted to the nursery of Korea University Hospital. We serially investigated the... |
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- Case Report
- Two Cases of Kabuki Make-up Syndrome Including One Case Associated with Xq Isochromosome
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Ki Hea Cho, Jung Hwa Lee, Kee Hyoung Lee, Kwang Chul Lee, Ji Tae Choung, Chang Sung Son, Young Chang Tockgo
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Clin Exp Pediatr. 2000;43(8):1111-1115. Published online August 15, 2000
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Kabuki make-up syndrome(KMS) is characterized by mental and developmental retardation and peculiar facial features including long palpebral fissures with eversion of the lateral portion of lower eyelid and arching of eyebrows, resembling the actors in Japanese Kabuki. In addition, dermatoglyphic and skeletal abnormalities are commonly associated. Although most karyotypes of KMS are shown to be normal, there have been some... |
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- Original Article
- Clinical Manifestations and Hematologic Complications of Epstein-Barr Virus Infection in Korean Children
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Seong Hoi Jeon, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee, Young Chang Tocko
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Clin Exp Pediatr. 1998;41(9):1216-1223. Published online September 15, 1998
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Purpose : Epstein-Barr virus(EBV) is associated with various diseases and complications caused by the host's immune reactions. This study focuses on various clinical findings and hematologic complications in childhood EBV infection.
Methods : The study group was thirty-eight EBV infected children(Anti-EBV VCA IgM; positive) who were admitted to the Department of Pediatrics, Korea University from January 1996 to July 1997. Patients... |
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- The Effect of Long-term Phenobarbital Administration on the Bone Mineral Density of Children
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Yoon Suck Suh, Young Guk Kim, Jung Hwa Lee, Kee Hwan Yoo, Joo Won Lee, Young Chang Tockgo
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Clin Exp Pediatr. 1994;37(3):368-375. Published online March 15, 1994
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The long term administration of anti-convulsants on children with convulsive disorders may cause osteomalacia, depending on the dosage, duration, type and combination of anti-convulsants administred. Fifteen children, comprising 10 male and 5 female, dignosed with convulsive disorders and administered with phenobarbital for a long term period of more than 9 months but less than 84 months and 15 healthy children... |
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- Case Report
- A Case of Congenital Hypoprothrombinemia
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Jong Kwang Lee, Hae Won Cheon, Jung Hwa Lee, Kwang Chul Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1994;37(3):422-429. Published online March 15, 1994
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Congenital hypoprothrombinemia is a rare congenital coagulation defect. The clinical signs are manifestation of generalized bleeding tendency such as; mucosal bleeding, hypermenorrhea and post tooth extraction hemorrage. It is associated with prolongation of PT and PTT with normal thrombin time and decreased serum prothrombin level.
A case with congenital hypoprothrombinemia was experienced by the authors. A 36 days old male baby... |
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- Original Article
- A Clinical Study on Early Diagnosis in Neonatal Sepsis
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Jong Kwang Lee, Hae Won Cheon, Jee Hee Park, Jung Hwa Lee, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 1993;36(1):49-56. Published online January 15, 1993
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Neonatal sepsis is a major contributing factor for increased mortality and morbidity in the newborn and its successful outcome depends on early detection and prompt institution of an effective antimicrobial therapy. Accurate diagnosis of the neonatal septicemia, however, is quite difficult because its early signs and symptoms are rather subtle.
This study was conducted in an attempt to search for useful... |
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